How to Silence Silencing

Ending the silence on gun violence … or silencing the debate?

Traffic into silence: endomembranes and post-transcriptional RNA silencing

microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-specific manner, resulting in mRNA deadenylation followed by exonucleolytic decay, mRNA endonucleolytic cleavage, or translational inhibition....

Welcome to Silence

Editorial Welcome to Silence [1], a new open-access journal devoted to RNA silencing and other pathways directed by non-coding RNAs. Silence springs from the extraordinary, yet brief, history of RNA silencing. In just two decades, we have seen the anomalous properties of plant and fungal transgenes connect with a series of amazing experiments in which injected double-stranded RNA triggered sile...

DAMD to epigenetic silence.

F or many decades, cancer research focused on genetic changes that led to tumorigenesis. However, it is now established that epigenetics also plays an important role in cancer initiation and development (1, 2). The cancer epigenome is marked by a global decrease in methylation, leading to genomic instability and increased methylation at promoters, which in turn leads to gene silencing (3). The ...

How to Use Glutaraldehyde

 الهای متمادی است که سرویس های بهداشتی گلوتار آلدئید را بعنوان یک ماده استریل کننده برای وسایلی که نسبت به گرما حساس هستند مورد استفاده قرار می دهند. همزمان با افزایش تقاضا برای استفاده از اندوسکوپی، استفاده از گلوتار آلدئید و تماس با آن نیز افزایش یافته است. باید خاطر نشان ساخت گلوتار آلدئید می تواند سبب ایجاد حساسیت های پوستی، چشمی و تنفسی گردد که نهایتاً امکان دارد این حساسیت به آسم و رنیت آل...